2018 Pritzker Distinguished Lecturer: Rashid Bashir
“BioMEMS and Biomedical Nanotechnology: From Lab on Chip to Printing Cellular Machines”
Department of Bioengineering
Carle Illinois College of Medicine
University of Illinois at Urbana-Champaign
Friday, April 13, 2018
1:50 p.m. – Wishnick Hall 113
Reception to follow
Integration of biology, medicine, and fabrication methods at the micro and nano scale offers tremendous opportunities for solving important problems in biology and medicine and to enable a wide range of applications in diagnostics, therapeutics, and tissue engineering. Microfluidics and Lab-on-Chip can be very beneficial to realize practical applications in detection of disease markers, counting of specific cells from whole blood, and for identification of pathogens, at point-of-care. The use of small sample size and electrical methods for sensitive analysis of target entities can result in easy to use, one-time-use assays that can be used at point-of-care. In this talk, we will present our work on detection of T cells for diagnostics of HIV AIDs for global health, development of a CBC (Complete Blood Cell) analysis on a chip, electrical detection of multiplexed nucleic acid amplification reactions, and detection of epigenetic markers on DNA at the single molecule level. While the above mentioned devices are built with PDMS or silicon using microfabrication approaches, bio-printing with stereolithography can be a very powerful technology to produce bio-hybrid devices made of polymers and cells such as biological machines and soft robotics. Such complex cellular systems will be a major challenge for the next decade and beyond, requiring knowledge from tissue engineering, synthetic biology, micro-fabrication and nanotechnology, systems biology, and developmental biology. As these “biological machines” increase in capabilities, exhibit emergent behavior, and potentially reveal the ability for self-assembly and self-repair, questions can arise about the ethical implications of this work. These devices could have potential applications in drug delivery, power generation, and other biomimetic systems.
This event is free and open to the IIT Community
2017 Pritzker Distinguished Lecturer Gordana Vunjak-Novakovic
“Engineering Human Tissues for Regenerative Medicine and Study of Disease”
Mikati Foundation Professor of Biomedical Engineering
Professor of Medical Sciences (in Medicine)
Director, Laboratory for Stem Cells and Tissue Engineering
Columbia University, New York
Friday, February 3, 2017 at 1:50 p.m.
Wishnick Hall, Room 113
Tissue engineering is becoming increasingly successful with authentically representing the actual environmental milieu of the development, regeneration and disease. A classical paradigm of tissue engineering is related to the integrated use of human cells, biomaterial scaffolds (structural and logistic templates for tissue formation) and bioreactors (culture systems providing environmental control, molecular and physical signaling) in regenerative medicine. Living human tissues can be bioengineered from the autologous stem cells, and tailored to the patient and the medical condition being treated.
More recently, the same principles are being successfully applied to the patient-specific “organs on a chip” platforms designed to recapitulate some aspects of human physiology. This talk will discuss some recent advances in regenerative engineering and modeling of disease using functional human tissues grown in lab.
Department of Biomedical Engineering Ph.D. Candidate: Shuo Yang
Investigation of von Willebrand Factor (VWF) Degradation under Controlled Shear Exposure
Robert A. Pritzker Endowed Chair in Engineering
Vincent Turitto, director of the Pritzker Institute of Biomedical Science and Engineering, was invested as the Robert A. Pritzker Endowed Chair in Engineering on August 10, 2011 in a private ceremony for the Pritzker and Turitto families.
Karen Pritzker funded the chair in honor of her father and University Regent Robert A. Pritzker, who graduated from Illinois Tech with an industrial engineering degree in 1946 and provided vision and leadership to the university for more than 50 years. Pritzker's foresight in establishing the Pritzker Institute of Biomedical Science and Engineering at Illinois Tech in 1980 has helped bring the university to the forefront of medical engineering research.
Turitto, who leads the Pritzker Institute, has made significant contributions to the expanding body of biomedical engineering research at Illinois Tech over the past decade. In addition to serving as director of the Pritzker Institute and chair of the Department of Biomedical Engineering, Turitto has authored more than 100 publications, received numerous research grants, and helped establish critical relationships between Illinois Tech and other medical research institutions.
"We are grateful to the Pritzker family for their many extraordinary contributions to the future of this university," said President John Anderson. "Endowed chairs are vital in ensuring retention of our best and brightest professors."
Pritzker Seminar Series
Neutrons and Their Application to Biomimetic Systems
Oak Ridge National Laboratory
Friday, October 28, 2011 at 3:30 p.m.
Illinois Institute of Technology
University Technology Park, Conference Room CD
Neutron and X-ray scattering are two of the most powerful structural determination techniques available today. Although many are familiar with the exploits of atomic resolution X-ray crystallography—in particular, protein crystallography—these techniques also have applications in polymer science, colloid chemistry, and materials science. Neutron scattering is ideally suited for the study of biological materials rich in hydrogen because of its ability to interact differentially with hydrogen and its isotope deuterium. It is also one of the few techniques capable of characterizing structure, dynamics, and interfacial relationships in complex biological systems. With the suite of neutron-scattering instruments suitable for the study of biological materials (e.g., small-angle scattering, diffraction, spectroscopy, and reflectometry) in place at the Spallation Neutron Source (SNS) and the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory, it is now possible to address questions of interest to the biological and medical communities. Today's seminar will give a brief overview of the neutron's history, its methods of production, and recent applications of neutron scattering to biologically relevant materials (e.g., cholesterol in PUFA bilayers; determination of lipid areas; neutrons and MD simulations).
BME's Sophia Pilipchuk Wins BMES 2011 Undergraduate Student Award
Illinois Tech biomedical engineering undergraduate senior Sophia Pilipchuk was named as one of five recipients of the Biomedical Engineering Society (BMES) Undergraduate Student Award, to be presented in October at the BMES Annual Business Meeting in Hartford, Connecticut.
Up to eight undergraduate students are selected from around the country on the basis of originality, significance, thoroughness of design analysis, and performance evaluation. Pilipchuk performs research on "Crosslinking of Tissue Derived Hydrogels" with BME doctoral student Marcella Vaicik and Associate Professor Eric Brey.
Undergraduate awards include a certificate, a complimentary registration for the Annual Meeting, and a stipend to assist with travel expenses.
Pritzker Seminar Series
November 15, 2010 at 1 p.m.
Impact of blood flow and chemical nature of vessel wall lesions on thrombus formation and anti-thrombotic efficacy.
Kjell S. Sakariassen, KellSa s.a.s., Italy
Location University Technology Park at Illinois Tech
Engineering Center for Diabetes Research and Education (ECDRE)
Omaditya “Goldey” Khanna, a senior CHBE student, won second place in the fall 2009 Annual Meeting of the Biomedical Engineering Society's research competition. His talk, “The Synthesis of Multilayered Alginate/Poly-L-Ornithine/Alginate Microcapsules and the Sustained-Release of Fibroblast Growth Factor-1 from the Outer Alginate Layer," conducts research with BME graduate student Monica Moya and BME Associate Professor Eric Brey.
Khanna published three peer-reviewed journal articles based on work performed in Brey's lab in 2010. Khanna was supported as a Ross Scholar during the summer of 2009.